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Review
. 2010 Sep 1;4(5):1248-55.
doi: 10.1177/193229681000400526.

The Sardinian way to type 1 diabetes

Marco Songini  1 , Cira Lombardo
Affiliations
Review

The Sardinian way to type 1 diabetes

Marco Songini et al. J Diabetes Sci Technol. .

Abstract

Sardinia and Finland are the "hottest" areas for type 1 diabetes mellitus (T1DM) worldwide. Its genetic and epidemiological background make Sardinia an ideal region for investigating environmental, immunological, and genetic factors related to the etiopathogenesis of T1DM. Consequently, in 1990, the Insulin-Dependent Diabetes Mellitus Sardinia Project was launched in order to map the geographical distribution of T1DM in the island and to investigate preclinical phases of T1DM in a large cohort of people genetically at risk. The final goal would be to design models of prediction and to formulate safe preventive measures, especially addressed to the general population living in areas at high risk.

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Figures

Figure 1
Figure 1
The T1DM incidence among children aged 0–14 years in Europe and in some Mediterranean countries based on EURODIAB data.
Figure 2
Figure 2
Incidence rate trend in Sardinia among children aged 0–14 years from 1989–1999 (p = .002).
Figure 3
Figure 3
Four Sardinian provinces.
Figure 4
Figure 4
Estimated risk of T1DM among children aged 0–14 years in the four Sardinian provinces from 1989–1999.
Figure 5
Figure 5
The T1DM incidence in Italy according to RIDI (Italian Registry of T1DM).
Figure 6
Figure 6
Secular trend of T1DM in Sardinia.
See this image and copyright information in PMC

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