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Clinical Trial
. 2010 Oct;126(4):875-8.
doi: 10.1016/j.jaci.2010.08.001.

IL-4 receptor α polymorphisms are predictors of a pharmacogenetic response to a novel IL-4/IL-13 antagonist

Rebecca E Slager, Gregory A Hawkins, Elizabeth J Ampleford, Alexandra Bowden, Lauren E Stevens, Matthew T Morton, Adrian Tomkinson, Sally E Wenzel, Malinda Longphre, Eugene R Bleecker, Deborah A Meyers
Clinical Trial

IL-4 receptor α polymorphisms are predictors of a pharmacogenetic response to a novel IL-4/IL-13 antagonist

Rebecca E Slager et al. J Allergy Clin Immunol. 2010 Oct.
No abstract available

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Figures

Figure 1
Figure 1
A, Human IL4RA SNP LD structure (r2) and associations with LAR ratio. Highly correlated SNPs (r2 > 0.7) have similar P values for association. The line indicates significance at P < 0.05; LD plot generated in Haploview v4.1. B, Mean (± standard deviation; SD) LAR ratio by IL4RA rs1801275 (Q576R) genotype and treatment group. C, Mean (±SD) LAR ratio by IL4RA rs1805011 (E400A) genotype and treatment group.
Figure 1
Figure 1
A, Human IL4RA SNP LD structure (r2) and associations with LAR ratio. Highly correlated SNPs (r2 > 0.7) have similar P values for association. The line indicates significance at P < 0.05; LD plot generated in Haploview v4.1. B, Mean (± standard deviation; SD) LAR ratio by IL4RA rs1801275 (Q576R) genotype and treatment group. C, Mean (±SD) LAR ratio by IL4RA rs1805011 (E400A) genotype and treatment group.
Figure 1
Figure 1
A, Human IL4RA SNP LD structure (r2) and associations with LAR ratio. Highly correlated SNPs (r2 > 0.7) have similar P values for association. The line indicates significance at P < 0.05; LD plot generated in Haploview v4.1. B, Mean (± standard deviation; SD) LAR ratio by IL4RA rs1801275 (Q576R) genotype and treatment group. C, Mean (±SD) LAR ratio by IL4RA rs1805011 (E400A) genotype and treatment group.
Figure 2
Figure 2
Map of human and Cynomolgus monkey IL4RA polymorphisms significantly associated with allergen-induced clinical outcomes. IL4RA introns and promoter are depicted in grey; exons and 3’ untranslated region in black. Genomic information primarily adapted from the human and Rhesus UCSC genome Browser. Rhesus sequence (the closest publically available sequence to Cynomolgus) contains gaps, therefore map is not to scale. Cyno IL4RA SNP LD plot and SNP correlation (r2) generated in Haploview v4.1.
See this image and copyright information in PMC

References

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    1. Kabesch M, Schedel M, Carr D, Woitsch B, Fritzsch C, Weiland SK, et al. IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma. J Allergy Clin Immunol. 2006;117:269–74. - PubMed
    1. Vercelli D. Genetics of IL-13 and functional relevance of IL-13 variants. Curr Opin Allergy Clin Immunol. 2002;2:389–93. - PubMed
    1. Wenzel SE, Balzar S, Ampleford E, Hawkins GA, Busse WW, Calhoun WJ, et al. IL4R alpha mutations are associated with asthma exacerbations and mast cell/IgE expression. Am J Respir Crit Care Med. 2007;175:570–6. - PMC - PubMed
    1. Howard TD, Koppelman GH, Xu J, Zheng SL, Postma DS, Meyers DA, et al. Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma. Am J Hum Genet. 2002;70:230–6. - PMC - PubMed

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