Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Oct;154(2):453-7.
doi: 10.1104/pp.110.161430.

Flavonoids and isoflavonoids: from plant biology to agriculture and neuroscience

Richard A Dixon  1 , Giulio M Pasinetti
Affiliations

Flavonoids and isoflavonoids: from plant biology to agriculture and neuroscience

Richard A Dixon et al. Plant Physiol. 2010 Oct.
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Flavonoid classes and an outline of their biosynthesis. A, The 2- and 3-phenylchroman skeletons. B, Schematic of flavonoid biosynthesis. Enzymes are CHS, chalcone isomerase (CHI), flavanone 3-β-hydroxyalse (F3H), flavonol synthase (FLS), and dihydroflavonol reductase (DFR). Anthocyanins are formed from leucoanthocyanidin (the product of DFR) and condensed tannins; PAs are formed from (epi)catechins, products of leucoanthocyanidin reductase or anthocyanidin reductase. 3-Phenylchromans (isoflavonoids) are formed via IFS. All classes of (iso)flavonoids can be further modified by substitution (e.g. O-methylation, glycosylation, C-prenylation).
Figure 2.
Figure 2.
Parallels between flavonoid metabolism, transport, and action in plants and humans.
See this image and copyright information in PMC

References

    1. Böhl M, Tietze S, Sokoll A, Madathil S, Pfennig F, Apostolakis J, Fahmy K, Gutzeit HO. (2007) Flavonoids affect actin functions in cytoplasm and nucleus. Biophys J 93: 2767–2780 - PMC - PubMed
    1. Butelli E, Titta L, Giorgio M, Mock HP, Matros A, Peterek S, Schijlen EGWM, Hall RD, Bovy AG, Luo J, et al. (2008) Enrichment of tomato fruit with health-promoting anthocyanins by expression of select transcription factors. Nat Biotechnol 26: 1301–1308 - PubMed
    1. Gomez C, Terrier N, Torregrosa L, Vialet S, Fournier-Level A, Verries C, Souquet JM, Mazauric JP, Klein M, Cheynier V, et al. (2009) Grapevine MATE-type proteins act as vacuolar H+-dependent acylated anthocyanin transporters. Plant Physiol 150: 402–415 - PMC - PubMed
    1. Grotewold E, Davies K. (2008) Trafficking and sequestration of anthocyanins. Nat Prod Commun 3: 1251–1258
    1. Hebert LE, Beckett LA, Scherr PA, Evans DA. (2001) Annual incidence of Alzheimer disease in the United States projected to the years 2000 through 2050. Alzheimer Dis Assoc Disord 15: 169–173 - PubMed

LinkOut - more resources