Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2010 Nov;56(5):819-21.
doi: 10.1161/HYPERTENSIONAHA.110.159350. Epub 2010 Oct 4.

Does interleukin 6 contribute to renal hemodynamic changes during angiotensin II-dependent hypertension?

Michael J Ryan
Editorial

Does interleukin 6 contribute to renal hemodynamic changes during angiotensin II-dependent hypertension?

Michael J Ryan. Hypertension. 2010 Nov.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Proposed role for inflammatory cytokines in angiotensin II dependent hypertension. Direct renal vascular effects of angiotensin II (and TNF-α) reduce renal blood flow (RBF) and glomerular filtration rate (GFR) to promote sodium retention. IL-6, stimulated directly by angiotensin II or indirectly through an angiotensin II mediated increase in TNF-α, activates JAK2/STAT3 signaling in the renal cortex which augments ENaC expression and sodium retention. The natriuretic actions of TNF-α partially counter the effects of impaired renal hemodynamics and IL-6 mediated increases in tubular reabsorption of sodium. The shaded boxes represent relationships that are directly tested, or supported indirectly as an association, in Brands et al .
See this image and copyright information in PMC

Comment on

Similar articles

See all similar articles

Cited by

  • Targeting inerleukin-6 for renoprotection.
    Gubernatorova EO, Samsonov MY, Drutskaya MS, Lebedeva S, Bukhanova D, Materenchuk M, Mutig K. Gubernatorova EO, et al. Front Immunol. 2024 Dec 11;15:1502299. doi: 10.3389/fimmu.2024.1502299. eCollection 2024. Front Immunol. 2024. PMID: 39723211 Free PMC article. Review.
  • Toll-like receptors and hypertension.
    Singh MV, Abboud FM. Singh MV, et al. Am J Physiol Regul Integr Comp Physiol. 2014 Sep 1;307(5):R501-4. doi: 10.1152/ajpregu.00194.2014. Epub 2014 Jun 11. Am J Physiol Regul Integr Comp Physiol. 2014. PMID: 24920728 Free PMC article. Review.

References

    1. Gudbrandsson T, Hansson L, Herlitz H, Lindholm L, Nilsson LA. Immunological changes in patients with previous malignant essential hypertension. Lancet. 1981;1:406–408. - PubMed
    1. Kristensen BO. Increased serum levels of immunoglobulins in untreated and treated essential hypertension. I. Relation to blood pressure. Acta Med Scand. 1978;203:49–54. - PubMed
    1. Svendsen UG. Spontaneous hypertension and hypertensive vascular disease in the NZB strain of mice. Acta Pathol Microbiol Scand A. 1977;85:548–554. - PubMed
    1. Chatelain RE, Vessey AR, Ferrario CM. Lymphoid alterations and impaired T lymphocyte reactivity in experimental renal hypertension. J Lab Clin Med. 1980;95:737–747. - PubMed
    1. Khraibi AA, Norman RA, Jr, Dzielak DJ. Chronic immunosuppression attenuates hypertension in Okamoto spontaneously hypertensive rats. Am J Physiol. 1984;247:H722–H726. - PubMed