[The nimesulide treatment of inflammation and posttraumatic pain in maxillofacial surgery. A controlled study versus flurbiprofen]

Abstract

Nimesulide has been employed in maxillofacial surgery so as to assess the drug's anti-pain and anti-inflammatory properties. The study was carried out in double blind controlled form, using flurbiprofen as a reference: both medications were administered in suppository form at a fixed dose of two per day, corresponding to 400 mg/die of nimesulide and 200 mg/die of flurbiprofen. Forty adult patients were entered into the experiment and they were assigned to one or other preparation at random until two groups of twenty units each had been formed. Duration of the treatment was just a little more than six days on average and at the end it was possible to conclude that the two therapies were useful in the whole constellation of parameters considered but with some diversification: nimesulide in fact showed an ability to resolve the inflammatory process more readily and consistently than the reference, a tendency that was also confirmed statistically. Tolerability of nimesulide was perfect. There was one episode of diarrhoea with the reference.