Drug Discovery in Academia- the third way?
- PMID: 20922062
- PMCID: PMC2948567
- DOI: 10.1517/17460441.2010.506508
Drug Discovery in Academia- the third way?
Abstract
As the pharmaceutical industry continues to re-strategise and focus on low-risk, relatively short term gains for the sake of survival, we need to re-invigorate the early stages of drug discovery and rebalance efforts towards novel modes of action therapeutics and neglected genetic and tropical diseases. Academic drug discovery is one model which offers the promise of new approaches and an alternative organisational culture for drug discovery as it attempts to apply academic innovation and thought processes to the challenge of discovering drugs to address real unmet need.
Similar articles
-
Navigating the Future of Cardiovascular Drug Development-Leveraging Novel Approaches to Drive Innovation and Drug Discovery: Summary of Findings from the Novel Cardiovascular Therapeutics Conference.Cardiovasc Drugs Ther. 2017 Aug;31(4):445-458. doi: 10.1007/s10557-017-6739-9. Cardiovasc Drugs Ther. 2017. PMID: 28735360 Review.
-
CNS Drug Discovery in Academia: Where Basic Research Meets Innovation.Chembiochem. 2024 Oct 1;25(19):e202400397. doi: 10.1002/cbic.202400397. Epub 2024 Jul 3. Chembiochem. 2024. PMID: 38958639 Review.
-
[Consideration on Industry-Academia Partnering in Drug Discovery Development: Based on a Questionnaire Survey of Pharmaceutical Companies and Academia].Yakugaku Zasshi. 2021 Jun 1;141(6):877-886. doi: 10.1248/yakushi.21-00006. Epub 2021 Mar 1. Yakugaku Zasshi. 2021. PMID: 33642438 Japanese.
-
Transparent collaboration between industry and academia can serve unmet patient need and contribute to reproductive public health.Hum Reprod. 2017 Aug 1;32(8):1549-1555. doi: 10.1093/humrep/dex230. Hum Reprod. 2017. PMID: 28854594 Free PMC article.
-
Guidelines, editors, pharma and the biological paradigm shift.Mens Sana Monogr. 2007 Jan;5(1):27-30. doi: 10.4103/0973-1229.32176. Mens Sana Monogr. 2007. PMID: 22058616 Free PMC article.
Cited by
-
Natural Products as Modulators of Sirtuins.Molecules. 2020 Jul 20;25(14):3287. doi: 10.3390/molecules25143287. Molecules. 2020. PMID: 32698385 Free PMC article. Review.
-
In Silico Prediction of Fraction Unbound in Human Plasma from Chemical Fingerprint Using Automated Machine Learning.ACS Omega. 2021 Mar 5;6(10):6791-6797. doi: 10.1021/acsomega.0c05846. eCollection 2021 Mar 16. ACS Omega. 2021. PMID: 33748592 Free PMC article.
-
Academic-Industrial Collaboration: Toward the Consilience of Two Solitudes.ACS Med Chem Lett. 2015 Dec 22;7(1):6-9. doi: 10.1021/acsmedchemlett.5b00488. eCollection 2016 Jan 14. ACS Med Chem Lett. 2015. PMID: 26819656 Free PMC article.
-
The transition to magic bullets - transition state analogue drug design.Medchemcomm. 2018 Aug 28;9(12):1983-1993. doi: 10.1039/c8md00372f. eCollection 2018 Dec 1. Medchemcomm. 2018. PMID: 30627387 Free PMC article. Review.
-
Chemsearch: collaborative compound libraries with structure-aware browsing.Bioinform Adv. 2021 Jul 16;1(1):vbab008. doi: 10.1093/bioadv/vbab008. eCollection 2021. Bioinform Adv. 2021. PMID: 36700113 Free PMC article.
References
-
- Hughes B. Nat. Rev. Drug Discovery. 2008;7:107–109. - PubMed
-
- Who will develop the next generation of medications for mental illness? NIMH Directors Blog. Mar 30, 2010. Available at http://www.nimh.nih.gov/about/director/2010/who-will-develop-the-next-ge....
-
- Cromelli D, Stolk P, Besançon L, et al. Pharmaceutical Sciences in 2020. Nat Rev Drug Discov. 2010;9:99–100. - PubMed
-
- Frantz S. How academia can help drug discovery. Nat. Rev. Drug Discovery. 2004;3:541. - PubMed
-
- Kozikowski AP, Roth B, Tropsha A. Why academic drug discovery makes sense. Science. 2006;313:1235–6. - PubMed
Grants and funding
LinkOut - more resources
Full Text Sources
Research Materials