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. 2010 Nov 15;25(15):2516-23.
doi: 10.1002/mds.23393.

Amyloid imaging of Lewy body-associated disorders

Erin R Foster  1 , Meghan C Campbell, Michelle A Burack, Johanna Hartlein, Hubert P Flores, Nigel J Cairns, Tamara Hershey, Joel S Perlmutter
Affiliations

Amyloid imaging of Lewy body-associated disorders

Erin R Foster et al. Mov Disord. .

Abstract

Clinicopathologic studies of Parkinson disease dementia (PDD) and dementia with Lewy bodies (DLB) commonly reveal abnormal β-amyloid deposition in addition to diffuse Lewy bodies (α-synuclein aggregates), but the relationship among these neuropathologic features and the development of dementia in these disorders remains uncertain. The purpose of this study was to determine whether amyloid-β deposition detected by PET imaging with Pittsburgh Compound B (PIB) distinguishes clinical subtypes of Lewy body-associated disorders. Nine healthy controls, 8 PD with no cognitive impairment, 9 PD with mild cognitive impairment, 6 DLB, and 15 PDD patients underwent [(11)C]-PIB positron emission tomography imaging, clinical examination, and cognitive testing. The binding potential (BP) of PIB for predefined regions and the mean cortical BP (MCBP) were calculated for each participant. Annual longitudinal follow-up and postmortem examinations were performed on a subset of participants. Regional PIB BPs and the proportion of individuals with abnormally elevated MCBP were not significantly different across participant groups. Elevated PIB binding was associated with worse global cognitive impairment in participants with Lewy body disorders but was not associated with any other clinical or neuropsychological features, including earlier onset or faster rate of progression of cognitive impairment. These results suggest that the presence of fibrillar amyloid-β does not distinguish between clinical subtypes of Lewy body-associated disorders, although larger numbers are needed to more definitively rule out this association. Amyloid-β may modify the severity of global cognitive impairment in individuals with Lewy body-associated dementia.

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Conflict of interest statement

All authors report no financial conflicts of interest related to this research.

Figures

Figure 1
Figure 1. PIB uptake for each participant subgroup
Mean cortical binding potentials (MCBPs) for the participant groups. Each point represents an individual participant.
See this image and copyright information in PMC

References

    1. Emre M. What causes mental dysfunction in Parkinson's disease? Movement Disorders. 2003;18(Suppl. 6):S63–S71. - PubMed
    1. Emre M, Aarsland D, Brown R, et al. Clinical diagnostic criteria for dementia associated with Parkinson's disease. Mov Disord. 2007;22(12):1689–1707. quiz 1837. - PubMed
    1. Hely MA, Reid WG, Adena MA, Halliday GM, Morris JG. The Sydney multicenter study of Parkinson's disease: the inevitability of dementia at 20 years. Mov Disord. 2008;23(6):837–844. - PubMed
    1. McKeith IG, Dickson DW, Lowe J, et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology. 2005;65(12):1863–1872. - PubMed
    1. Aarsland D, Perry R, Brown A, Larsen JP, Ballard C. Neuropathology of dementia in Parkinson's disease: a prospective, community-based study. Ann Neurol. 2005;58(5):773–776. - PubMed

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