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Review
. 2010 Nov 8;12(6):765-806.
doi: 10.1021/cc100128w. Epub 2010 Oct 5.

Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2009

Roland E Dolle  1 , Bertrand Le Bourdonnec, Karin Worm, Guillermo A Morales, Craig J Thomas, Wei Zhang
Affiliations
Review

Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2009

Roland E Dolle et al. J Comb Chem. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
HDAC1/HDAC2 inhibitors.
Figure 2
Figure 2
Histamine H3 antagonists.
Figure 3
Figure 3
Glucogon receptor antagonists.
Figure 4
Figure 4
P2Y12 receptor antagonists.
Figure 5
Figure 5
Hsp90 inhibitors.
Figure 6
Figure 6
Selective noradrenaline reuptake inhibitors.
Figure 7
Figure 7
Positive allosteric modulators of mGluR4.
Figure 8
Figure 8
mGluR5 allosteric modulators.
Figure 9
Figure 9
Figure 9a. Bcl-2 inhibitors via DOS library. Figure 9b. Bcl-2 inhibitors via DOS library (continued).
Figure 9
Figure 9
Figure 9a. Bcl-2 inhibitors via DOS library. Figure 9b. Bcl-2 inhibitors via DOS library (continued).
Figure 10
Figure 10
Catch and release synthesis of substituted guanidines.
Figure 11
Figure 11
MCR to pyrimidine derivatives.
Figure 12
Figure 12
Discovery of Ned-19.
Figure 13
Figure 13
Discovery of DG-041.
Figure 14
Figure 14
Fluorous dihydropyran linker.
Figure 15
Figure 15
Fluorous isonitrile linker.
Figure 16
Figure 16
Fluorous synthesis of 1,4-benzodiazepinedione library.
Figure 17
Figure 17
Fluorous synthesis of tricyclic library.
Figure 18
Figure 18
Fluorous mixture synthesis of resorcylic acid lactone library.
See this image and copyright information in PMC

References

    1. Dolle RE, Le Bourdonnec B, Goodman AJ, Morales GA, Thomas CJ, Zhang W. J Comb Chem. 2009;11:739–790. - PubMed
    1. Abadi AH, Ibrahim TM, Abouzid KM, Lehmann J, Tinsley HN, Gary BD, Piazza GA. Bioorg Med Chem. 2009;17:5974–5982. - PMC - PubMed
    1. Adib M, Kesheh MR, Ansari S, Bijanzadeh HR. Synlett. 2009:1575–1578.
    1. Aguado L, Camarasa M-J, Perez-Perez M-J. J Comb Chem. 2009;11:210–212. - PubMed
    1. Airiau E, Girard N, Mann A, Salvadori J, Taddei M. Org Lett. 2009;11:5314–5317. - PubMed

MeSH terms