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. 2010 Nov 15;202(10):1562-6.
doi: 10.1086/656913. Epub 2010 Oct 5.

Class I HLA-A*7401 is associated with protection from HIV-1 acquisition and disease progression in Mbeya, Tanzania

Rebecca N Koehler  1 , Anne M Walsh, Elmar Saathoff, Sodsai Tovanabutra, Miguel A Arroyo, Jeffery R Currier, Leonard Maboko, Michael Hoelscher, Merlin L Robb, Nelson L Michael, Francine E McCutchan, Jerome H Kim, Gustavo H Kijak
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Class I HLA-A*7401 is associated with protection from HIV-1 acquisition and disease progression in Mbeya, Tanzania

Rebecca N Koehler et al. J Infect Dis. .

Erratum in

  • J Infect Dis. 2011 Mar;203(5):749. Hoelsher, Michael [corrected to Hoelscher, Michael]

Abstract

Here we explore associations between HLA variation and human immunodeficiency virus type 1 (HIV-1) acquisition and disease progression in a community cohort in Mbeya, Tanzania, a region that, despite harboring high rates of HIV-1 infection, remains understudied. African-specific allele HLA-A*74:01 was associated with decreased risk of infection (odds ratio [OR], 0.37; 95% confidence interval [CI], 0.14-0.80; P = .011) and with protection from CD4(+) cell counts <200 cells/uL in women (OR, 0.31; 95% CI, 0.07-0.91; P = .032) and men (OR, 0.15; 95% CI, 0.01-0.78; P = .020). These associations remained significant after adjustment for linkage disequilibrium with HLA-B and HLA-C alleles. This observation calls for additional investigation of mechanisms by which HLA-A*74:01 may influence HIV-1 acquisition and control of the infection.

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