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. 2010 Nov;63(11):685-7.
doi: 10.1038/ja.2010.107. Epub 2010 Oct 6.

The psychotrimine natural products have antibacterial activity against Gram-positive bacteria and act via membrane disruption

Mark A Schallenberger  1 , Timothy Newhouse, Phil S Baran, Floyd E Romesberg
Affiliations

The psychotrimine natural products have antibacterial activity against Gram-positive bacteria and act via membrane disruption

Mark A Schallenberger et al. J Antibiot (Tokyo). 2010 Nov.
No abstract available

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Figures

Figure 1
Figure 1
Structure of psychotrimine (1) and derivatives 2 and 3.
Figure 2
Figure 2
(a) Viable cell count following psychotrimine treatment of S. aureus (filled) and B. subtilis (open); and (b) absorption at 260 nm of supernatant from S. aureus cells following antibiotic treatment in phosphate buffered saline (normalized for absorption of the antibiotic). Error bars represent standard deviation of at least three independent experiments.
See this image and copyright information in PMC

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