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Comment
. 2010 Oct;17(10):1164-5.
doi: 10.1038/nsmb1010-1164.

The molecular principles of N-end rule recognition

Shashikanth M Sriram  1 , Yong Tae Kwon
Affiliations
Comment

The molecular principles of N-end rule recognition

Shashikanth M Sriram et al. Nat Struct Mol Biol. 2010 Oct.

Abstract

The N-end rule pathway is a proteolytic system in which recognition components (N-recognins) recognize a set of N-terminal residues as part of degradation signals (N-degrons). Two studies in this issue report the structures of Ubr boxes, a substrate recognition domain of eukaryotic N-recognins. We discuss how eukaryotic and prokaryotic N-recognins use a similar molecular principle to recognize a different set of N-degrons.

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References

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    1. Mol Cell Biol. 2005 Aug;25(16):7120-36 - PubMed
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