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. 2010 Oct;44(4):363-8.
doi: 10.4103/0019-5413.69304.

Pathology of Ewing's sarcoma/PNET: Current opinion and emerging concepts

Saral S Desai  1 , Nirmala A Jambhekar
Affiliations

Pathology of Ewing's sarcoma/PNET: Current opinion and emerging concepts

Saral S Desai et al. Indian J Orthop. 2010 Oct.

Abstract

Ewing's sarcoma/PNET are small round cell tumors showing a varying degree of neuroectodermal differentiation. They are one of the commonest tumors of childhood and occur in bone and within soft tissues. Traditionally, light microscopy with the aid of immunohistochemical stains was suitable for diagnosis. But now translocation analyses are being used not only for the diagnosis and classification of small round cell tumors, but to ascertain their prognostic significance, detect micrometastasis, and monitor minimal residual disease, with potential for targeted therapy. This article analyzes the pathology, biology, and molecular aspects of Ewing's sarcoma/PNET and discusses their clinical and therapeutic implications.

Keywords: EWS-FLI1 translocation; Ewing’s sarcoma; PNET; pathology.

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Conflict of interest statement

Conflict of Interest: None.

Figures

Figure 1
Figure 1
ES/PNET composed of sheets of small round blue cells
Figure 2
Figure 2
The tumor cells of EFT show membranous expression of CD99/MIC2 (left), and nuclear positivity for antibodies against FLI1 (right)
See this image and copyright information in PMC

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