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. 2010 Oct 15;16(20):4909-11.
doi: 10.1158/1078-0432.CCR-10-2005. Epub 2010 Oct 5.

The tissue is the issue: personalized medicine for non-small cell lung cancer

Fred R Hirsch  1 , Murry W Wynes, David R Gandara, Paul A Bunn Jr
Affiliations

The tissue is the issue: personalized medicine for non-small cell lung cancer

Fred R Hirsch et al. Clin Cancer Res. .

Abstract

The development of molecular markers is crucial for improving therapy in advanced non-small cell lung cancer (NSCLC). Here, we review perspectives of biomarker-driven personalized therapy in NSCLC, with particular reference to the detection of EML4-ALK gene rearrangements. Different molecular assays, validation, and clinical application to different types of tissue specimens are discussed.

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