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. 2010 Aug;42(4):243-4.
doi: 10.4103/0253-7613.68433.

Unusual nail pigmentation following cyclophosphamide-containing chemotherapy regimen

Santosh Kumar  1 , Rakesh Dixit, Saurabh Karmakar, Sayan Paul
Affiliations

Unusual nail pigmentation following cyclophosphamide-containing chemotherapy regimen

Santosh Kumar et al. Indian J Pharmacol. 2010 Aug.

Abstract

Cyclophosphamide therapy may rarely cause pigmentation of the nails which is of different patterns. We report a patient who developed pigmentation of nails after six cycles of cyclophosphamide, methotrexate, and 5-flourouracil chemotherapy, each repeated after 28 days for breast cancer. The patient developed nail pigmentation that started proximally and spread distally and involved all the nails of both hands and feet except the second and third toenails of right foot. Using Naranjo ADR Probability Scale, the case revealed a "probable" association with cyclophosphamide.

Keywords: Chemotherapy; cyclophosphamide; nail pigmentation.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Nails of both hands pigmented more deeply than the toenails.
Figure 2
Figure 2
Pigmentation of nails of both feet with sparing of the nails of the IInd and IIIrd toe of the right foot.
See this image and copyright information in PMC

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