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. 2010;33(10):1751-3.
doi: 10.1248/bpb.33.1751.

Association of the A-1438G polymorphism in serotonin 2A receptor in migraine with aura among Japanese patients

Yuika Naito  1 , Masakazu Ishii, Ayumu Nagamine, Atsuko Imagawa, Kenji Shida, Johji Takahashi, Yukiko Hosaka, Yuko Naito, Hideto Oyamada, Shunichi Shimizu, Katsuji Oguchi, Hajime Hara, Yutaka Masuda, Shino Usami, Yuji Kiuchi
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Free article

Association of the A-1438G polymorphism in serotonin 2A receptor in migraine with aura among Japanese patients

Yuika Naito et al. Biol Pharm Bull. 2010.
Free article

Abstract

We investigated the possible association of serotonin (5-HT) 2A receptor gene A-1438G polymorphism in Japanese patients with migraine. Genotyping of 5-HT(2A) A-1438G polymorphism was performed by polymerase chain reaction-restriction fragment length polymorphism in patients with migraine (male 17 : 3 with aura and 14 without aura, female 65 : 17 with aura and 48 without aura) and controls (male 31, female 84). The distribution of 5-HT(2A) A-1438G genotype frequency between migraine patients and controls did not differ. These results suggest that the A-1438G polymorphism of the 5-HT(2A) receptor gene is not a direct risk factor for migraine; however, the incidence of the A/A genotype between migraine with aura (MA) and without aura (MO) was significantly different. The 5-HT(2A) A-1438G polymorphism may be involved in determining the subtypes of migraine in Japanese.

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