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Comment
. 2010 Sep 15;9(18):3645-6.
doi: 10.4161/cc.9.18.13221. Epub 2010 Sep 15.

Incapacitating CtBP to kill cancer

Ling-Zun Zhao, G Chinnadurai
Comment

Incapacitating CtBP to kill cancer

Ling-Zun Zhao et al. Cell Cycle. .
No abstract available

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Figures

Figure 1
Figure 1
(A) Transcriptional repression of tumor suppressors and apoptotic genes by the CtBP dimer under normal conditions. CtBP is recruited to the target promoter through interaction with the PLDLS-like motif in the repressor which is anchored to the target promoter. The second subunit in the CtBP dimer interacts with DNA-modifying enzymes including HDACs and LSD-1. Epigenetic modifications of the chromatin by the CtBP complex result in gene silencing. NAD+/NADH binding domain and substrate (MTOB)-binding domain are illustrated. (B) Transcriptional activation of tumor suppressors and apoptotic genes after binding of MTOB to CtBP. MTOB binding to the substrate-binding domain of CtBP might induce conformational changes in the PLDLS-binding cleft and cause dissociation of the CtBP complex from the repressor, resulting in derepression of the target genes.
See this image and copyright information in PMC

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References

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