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. 2010 Jul;27(3):138-40.
doi: 10.4103/0970-2113.68312.

Evaluation of serum immunoglobulin E levels in bronchial asthma

Thirunavukkarasu Sandeep  1 , Mysore Subrahmanyam Roopakala, Chickballapur Rayappa Wilma Delphine Silvia, Srikantaiah Chandrashekara, Mohan Rao
Affiliations

Evaluation of serum immunoglobulin E levels in bronchial asthma

Thirunavukkarasu Sandeep et al. Lung India. 2010 Jul.

Abstract

Background: Immunoglobulin E and associated cellular responses are responsible for allergic airway diseases. A hypersensitivity reaction initiated by immunologic mechanisms, mediated by IgE antibodies occurs in allergic asthma

Aim: To estimate and compare serum IgE levels in mild, moderate, and severe asthmatics and in normal subjects and to obtain a mathematical model describing the relationship between serum IgE levels and severity of asthma.

Materials and methods: A stratified sample of 60 patients within age group of 18-60 years and 31 male and 29 female asthmatic patients and 13 healthy controls within 18-60 years were included in this study and classified according to GINA classification. Serum IgE levels were estimated by using ELISA kit.

Results: Mean IgE levels ranged from 151.95 IU/ml in normal subjects to 1045.32 IU/ml in severe asthmatics. The model developed was 27% efficient.

Conclusion: Serum Immunoglobulin E levels were high in asthmatics as compared to normal subjects. On an average, the levels increased as the severity of asthma increased. However, there was no statistically significant correlation since the variability in each level of asthma was very large.

Keywords: Allergy; bronchial asthma; immunoglobulin E; inflammation.

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Conflict of interest statement

Conflict of Interest: None declared.

References

    1. Paramesh H. Epidemiology of Asthma in India. Indian J Pediatr. 2002;69:309–12. - PMC - PubMed
    1. Peng Z. Vaccines targeting IgE in asthma and allergy. Hum Vaccine. 2009;18:5. - PubMed
    1. Rage E, Jacquemin B, Nadif R, Oryszczyn MP, Siroux V, Aguilera I, et al. Total serum IgE levels are associated with ambient ozone concentration in asthmatic adults. Allergy. 2009;64:40–6. - PubMed
    1. Buhl R. Anti-IgE antibodies for the treatment of asthma. Curr Opin Pulm Med. 2005;11:27–34. - PubMed
    1. Bethesda Global strategy for asthma management and prevention. National Institutes of Health. NHBLI Workshop Report. 2002;2:3659.