Decrease of collagen biosynthesis ability of rat kidney fibroblasts transformed with SV--40 virus
- PMID: 209313
- DOI: 10.1007/BF00241385
Decrease of collagen biosynthesis ability of rat kidney fibroblasts transformed with SV--40 virus
Abstract
Rat kidney fibroblasts transformed with SV-40 produce "in vitro" a significantly lower amount of hydroxyproline-containing material which is collagenase sensitive as compared to normal cells. In contrast to normal fibroblast cultures, no collagenous material was found by histochemical methods in intercellular spaces of transformed cultures.