GM1 ganglioside reduces cognitive dysfunction after focal cortical ischemia
- PMID: 2093171
- DOI: 10.1016/0091-3057(90)90546-t
GM1 ganglioside reduces cognitive dysfunction after focal cortical ischemia
Abstract
The functional consequences of cortical focal ischemia and the effect of monosialoganglioside (GM1) treatment on learning/performance of a spatial reversal task were investigated. Cortical focal ischemia was induced by a permanent occlusion of the left common carotid artery and the ipsilateral middle cerebral artery, with a 1-h clamping of the contralateral carotid artery. Twenty-six rats were randomly assigned to three groups: sham controls, a saline-treated ischemic group, and a GM1 ganglioside-treated ischemic group (10 mg/kg/day: IM). Fifteen days after surgery rats were trained on a spatial reversal task in a two-lever operant chamber where food reward was contingent on lever pressing. Training continued from day 15 to day 21 after surgery. Cortical focal ischemia resulted in learning/performance deficits that were reduced by GM1 ganglioside treatment. The cognitive deficits were characterized by a significantly higher number of nonperseverative errors and number of responses to criterion. There was a significant difference between left and right lever performance in the saline-treated ischemic group, which was absent in shams and GM1-treated ischemic rats. On all measures GM1-treated rats were not different from sham controls.
Similar articles
-
GM1 reduces infarct volume after focal cerebral ischemia.Exp Neurol. 1994 Feb;125(2):278-85. doi: 10.1006/exnr.1994.1030. Exp Neurol. 1994. PMID: 8313942
-
Loss and recovery of activities of alpha+ and alpha isozymes of (Na(+) + K+)-ATPase in cortical focal ischemia: GM1 ganglioside protects plasma membrane structure and function.J Neurosci Res. 1992 Jun;32(2):209-20. doi: 10.1002/jnr.490320210. J Neurosci Res. 1992. PMID: 1328661
-
Temporal changes in edema, Na+, K+, and Ca++ in focal cortical stroke: GM1 ganglioside reduces ischemic injury.J Neurosci Res. 1991 Nov;30(3):512-20. doi: 10.1002/jnr.490300308. J Neurosci Res. 1991. PMID: 1800772
-
Pathophysiology of Ganglioside GM1 in Ischemic Stroke: Ganglioside GM1: A Critical Review.Cell Transplant. 2019 Jun;28(6):657-661. doi: 10.1177/0963689718822782. Epub 2019 Jan 22. Cell Transplant. 2019. PMID: 30666888 Free PMC article. Review.
-
Monosialoganglioside GM1 in cerebral ischemia.Cerebrovasc Brain Metab Rev. 1991 Summer;3(2):134-57. Cerebrovasc Brain Metab Rev. 1991. PMID: 1854596 Review.
Cited by
-
Ganglioside GM1 and the Central Nervous System.Int J Mol Sci. 2023 May 31;24(11):9558. doi: 10.3390/ijms24119558. Int J Mol Sci. 2023. PMID: 37298512 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources