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. 2010 Dec;45(12):6095-100.
doi: 10.1016/j.ejmech.2010.09.024. Epub 2010 Sep 17.

Synthesis and antitubercular activity of new mefloquine-oxazolidine derivatives

Raoni S B Gonçalves  1 , Carlos R Kaiser, Maria C S Lourenço, Marcus V N de Souza, James L Wardell, Solange M S V Wardell, Adilson D da Silva
Affiliations

Synthesis and antitubercular activity of new mefloquine-oxazolidine derivatives

Raoni S B Gonçalves et al. Eur J Med Chem. 2010 Dec.

Abstract

In this work, we report the synthesis and the antitubercular evaluation of 16 new mefloquine derivatives, formed from reactions between mefloquine and benzaldehydes, with the activity expressed as the minimum inhibitory concentration (MIC) in μM. The compounds were non-cytotoxic and exhibited an important activity (12.6 μM). The appreciable activity of these compounds can be considered an important finding for the rational design of new leads for anti-TB compounds.

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