Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Dec;45(12):6095-100.
doi: 10.1016/j.ejmech.2010.09.024. Epub 2010 Sep 17.

Synthesis and antitubercular activity of new mefloquine-oxazolidine derivatives

Affiliations

Synthesis and antitubercular activity of new mefloquine-oxazolidine derivatives

Raoni S B Gonçalves et al. Eur J Med Chem. 2010 Dec.

Abstract

In this work, we report the synthesis and the antitubercular evaluation of 16 new mefloquine derivatives, formed from reactions between mefloquine and benzaldehydes, with the activity expressed as the minimum inhibitory concentration (MIC) in μM. The compounds were non-cytotoxic and exhibited an important activity (12.6 μM). The appreciable activity of these compounds can be considered an important finding for the rational design of new leads for anti-TB compounds.

PubMed Disclaimer

MeSH terms

LinkOut - more resources