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Review
. 2010 Dec;42(12):1907-10.
doi: 10.1016/j.biocel.2010.09.021.

Colorectal cancer cells - Proliferation, survival and invasion by lysophosphatidic acid

Sei-Jung Lee  1 , C Chris Yun
Affiliations
Review

Colorectal cancer cells - Proliferation, survival and invasion by lysophosphatidic acid

Sei-Jung Lee et al. Int J Biochem Cell Biol. 2010 Dec.

Abstract

Colorectal cancer (CRC) develops through a series of genetic modifications that transforms normal colonic epithelium to an adenoma and then ultimately adenocarcinoma. A body of evidence suggests that lysophosphatidic acid (LPA) is a potent inducer of cancer progression at multiple levels. However, the pathological significance and mechanisms of LPA-mediated effects in the intestinal tract have only recently drawn interests. CRC cells have aberrant LPA receptor expression and LPA enhances proliferation, survival, and invasion of CRC cells, implying LPA and its signaling pathways as potential targets for anti-cancer therapies. The mechanisms of fostering CRC by LPA include dysregulation of transcription factors, activation of mitogen-activated protein kinases, pro-inflammatory cytokines, and angiogenic factors. This review provides a brief summary of recent advance on the effects of LPA on CRC cells.

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Figures

Figure 1
Figure 1. Signaling pathways in intestinal epithelial cells
LPA1 regulates cell proliferation and migration. LPA2 interacts with several PDZ proteins. LPA2 is the major LPA receptor that regulates colon cancer cells. LPA acting LPA3 shows significant involvement in migration and inflammation. In addition, LPA regulates electrolyte and fluid transport in the intestinal tract.
See this image and copyright information in PMC

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