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. 1990 Dec 24;194(2-3):167-72.
doi: 10.1016/0009-8981(90)90131-b.

Inhibition of protein kinase C activation by low concentrations of aluminium

M Cochran  1 , D C Elliott, P Brennan, V Chawtur
Affiliations

Inhibition of protein kinase C activation by low concentrations of aluminium

M Cochran et al. Clin Chim Acta. .

Abstract

An extract of rat brain protein kinase C was fully activated at a total calcium concentration 3 x 10(-4) mol/l (Ca2+ 10(-4) mol/l) in the presence of non-limiting concentrations of phosphatidylserine. Available aluminium (ionised plus soluble hydrolysed) at a median value of 2 x 10(-8) mol/l inhibited enzyme activation by 90% at this non-limiting calcium concentration. Literature values for tissue aluminium concentrations suggest that interference with this key intracellular regulatory protein might occur in vivo.

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