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Randomized Controlled Trial
. 2011 Jan;40(1):77-86.
doi: 10.1016/j.jsat.2010.08.010. Epub 2010 Oct 8.

Bupropion SR and contingency management for adolescent smoking cessation

Kevin M Gray  1 , Matthew J Carpenter, Nathaniel L Baker, Karen J Hartwell, A Lee Lewis, D Walter Hiott, Deborah Deas, Himanshu P Upadhyaya
Affiliations
Randomized Controlled Trial

Bupropion SR and contingency management for adolescent smoking cessation

Kevin M Gray et al. J Subst Abuse Treat. 2011 Jan.

Abstract

There is a significant need for evidence-based treatments for adolescent smoking cessation. Prior research, although limited, has suggested potential roles for bupropion sustained-release (SR) and contingency management (CM), but no previous studies have assessed their combined effect. In a double-blind, placebo-controlled design, 134 adolescent smokers were randomized to receive a 6-week course of bupropion SR + CM, bupropion SR + non-CM, placebo + CM, or placebo + non-CM, with final follow-up at 12 weeks. The primary outcome was 7-day cotinine-verified point prevalence abstinence, allowing for a 2-week grace period. Combined bupropion SR + CM treatment yielded significantly superior abstinence rates during active treatment when compared with placebo + non-CM treatment. In addition, combined treatment showed greater efficacy at multiple time points than did either bupropion SR + non-CM or placebo + CM treatment. Combined bupropion SR and CM appears efficacious, at least in the short-term, for adolescent smoking cessation and may be superior to either intervention alone.

Trial registration: ClinicalTrials.gov NCT00330187.

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Figures

Figure 1
Figure 1
Participant enrollment flow chart.
See this image and copyright information in PMC

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