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Comment
. 2010 Oct 26;107(43):18241-2.
doi: 10.1073/pnas.1013177107. Epub 2010 Oct 8.

Population genetics meets cancer genomics

Roland R Regoes  1
Affiliations
Comment

Population genetics meets cancer genomics

Roland R Regoes. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

Conflict of interest statement: Martin Nowak, the last author of Bozic et al. (6), was the author's master's degree thesis advisor (1996–1998).

Figures

Fig. 1.
Fig. 1.
Sketch of the multitype branching process developed by Bozic et al. (6). A tumor start with one cell carrying a single driver mutation (D). This cell may either die or divide, and it can further mutate. The probabilities of these events are indicated. They depend on the number of driver mutations the cell carries and the selection coefficient s. Driver mutations arise in one of the daughter cells at division with a probability of u = 3.4 × 105. The model assumes discrete generations with a length of 4 d. Passenger mutations (not shown in this sketch) are accumulated at a rate of v = 0.016 from generation to generation.
See this image and copyright information in PMC

Comment on

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