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Case Reports
. 2011 Jan 6;117(1):242-5.
doi: 10.1182/blood-2010-06-291658. Epub 2010 Oct 8.

A novel NUP98/RARG gene fusion in acute myeloid leukemia resembling acute promyelocytic leukemia

Esperanza Such  1 , José Cervera, Ana Valencia, Eva Barragán, Mariam Ibañez, Irene Luna, Oscar Fuster, Maria Luz Perez-Sirvent, Leonor Senent, Amparo Sempere, Jesús Martinez, Guillermo Martín-Aragonés, Miguel A Sanz
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Free article
Case Reports

A novel NUP98/RARG gene fusion in acute myeloid leukemia resembling acute promyelocytic leukemia

Esperanza Such et al. Blood. .
Free article

Abstract

Chromosomal translocations in hematological malignancies often result in novel fusion chimeric genes. We report a case of acute myeloid leukemia with a clonal translocation t(11;12)(p15;q13) displaying morphologic and immunophenotypic features resembling the classical hypergranular subtype of acute promyelocytic leukemia. The gene fused to NUP98 (nucleoporin 98) was detected by comparative genomic hybridization array as the retinoid acid receptor gamma gene (RARG). The involvement of RARG in a chimeric fusion transcript has not been reported previously in human leukemia.

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