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. 1978 Jun;303(2):193-6.
doi: 10.1007/BF00508068.

Alpha-receptor-mediated modulation of 3H-noradrenaline release from rat brain cortex synaptosomes

A H Mulder, C D de Langen, V de Regt, F Hogenboom

Alpha-receptor-mediated modulation of 3H-noradrenaline release from rat brain cortex synaptosomes

A H Mulder et al. Naunyn Schmiedebergs Arch Pharmacol. 1978 Jun.

Abstract

The effects of oxymetazoline and noradrenaline (in the presence of desipramine) on the release of 3H-noradrenaline from rat brain cortex synaptosomes were studied using a superfusion technique. Both drugs (at 1 micrometer concentrations) were found to reduce the depolarization-induced (15 mM K+) release of 3H-noradrenaline. The release-modulating effect of noradrenaline was antagonized by phentolamine and yohimbine. The data provide direct evidence for the hypothesis that alpha-receptors modulating the release of noradrenaline are localized on varicosities of central noradrenergic neurones.

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