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. 2010 Nov;13(11):1354-6.
doi: 10.1038/nn.2654. Epub 2010 Oct 10.

The habenula is crucial for experience-dependent modification of fear responses in zebrafish

Masakazu Agetsuma  1 , Hidenori Aizawa, Tazu Aoki, Ryoko Nakayama, Mikako Takahoko, Midori Goto, Takayuki Sassa, Ryunosuke Amo, Toshiyuki Shiraki, Koichi Kawakami, Toshihiko Hosoya, Shin-ichi Higashijima, Hitoshi Okamoto
Affiliations

The habenula is crucial for experience-dependent modification of fear responses in zebrafish

Masakazu Agetsuma et al. Nat Neurosci. 2010 Nov.

Abstract

The zebrafish dorsal habenula (dHb) shows conspicuous asymmetry in its connection with the interpeduncular nucleus (IPN) and is equivalent to the mammalian medial habenula. Genetic inactivation of the lateral subnucleus of dHb (dHbL) biased fish towards freezing rather than the normal flight response to a conditioned fear stimulus, suggesting that the dHbL-IPN pathway is important for controlling experience-dependent modification of fear responses.

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References

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