Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Feb;30(2):289-91.
doi: 10.1007/s10096-010-1084-y. Epub 2010 Oct 10.

Local imipenem activity against Pseudomonas aeruginosa decreases in vivo in the presence of siliconized latex

C Pichardo  1 , M C Conejo, F Docobo-Pérez, C Velasco, R López-Rojas, I García, M E Pachón-Ibáñez, J M Rodríguez, J Pachón, A Pascual
Affiliations

Local imipenem activity against Pseudomonas aeruginosa decreases in vivo in the presence of siliconized latex

C Pichardo et al. Eur J Clin Microbiol Infect Dis. 2011 Feb.

Abstract

Zinc eluted from siliconized latex (SL) increases resistance of Pseudomonas aeruginosa to imipenem in vitro. A foreign body peritonitis model was used to evaluate the activity of imipenem using SL or silicone (S) implants. No differences were observed in mortality, positive blood cultures and tissue bacterial counts between SL and S implants. Implant-associated counts, however, were significantly higher in the SL group. It is concluded that SL decreases the activity of imipenem against P. aeruginosa.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Antimicrob Agents Chemother. 2003 Jul;47(7):2313-5 - PubMed
    1. Clin Infect Dis. 2010 Mar 1;50(5):625-63 - PubMed
    1. J Biol Chem. 2004 Mar 5;279(10):8761-8 - PubMed
    1. Antimicrob Agents Chemother. 1999 Feb;43(2):397-9 - PubMed
    1. Med Clin (Barc). 2007 Nov 17;129(18):707-15 - PubMed

Publication types

MeSH terms

LinkOut - more resources