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Clinical Trial
. 1990;22(6):561-6.
doi: 10.1007/BF02549745.

The effect of sulphinpyrazone and alpha-tocopherol on platelet activation and function in haemodialysed patients

A Dmoszyńska-Giannopoulou  1 , L Janicka, B Sokołowska, A Ksiazek, G Orłowska, K Janicki
Affiliations
Clinical Trial

The effect of sulphinpyrazone and alpha-tocopherol on platelet activation and function in haemodialysed patients

A Dmoszyńska-Giannopoulou et al. Int Urol Nephrol. 1990.

Abstract

In 30 patients on chronic haemodialysis treatment the platelet activity and function were studied before and during antiplatelet therapy with alpha-tocopherol and sulphinpyrazone. In both kinds of treatment a significant decrease of ADP-induced and spontaneous aggregation was observed. Sulphinpyrazone exerts an inhibitory effect not only on platelet aggregation but also on platelet factor 3 and provokes a significant prolongation of the bleeding time.

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