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. 2011 Jan;24(1):90-5.
doi: 10.1038/ajh.2010.193. Epub 2010 Sep 9.

Arterial stiffness and gait speed in older adults with and without peripheral arterial disease

Nora L Watson  1 , Kim Sutton-Tyrrell, Ada O Youk, Robert M Boudreau, Rachel H Mackey, Eleanor M Simonsick, Caterina Rosano, Susan E Hardy, B Gwen Windham, Tamara B Harris, Samer S Najjar, Edward G Lakatta, Hal H Atkinson, Karen C Johnson, Douglas C Bauer, Anne B Newman; Health ABC Study
Affiliations

Arterial stiffness and gait speed in older adults with and without peripheral arterial disease

Nora L Watson et al. Am J Hypertens. 2011 Jan.

Erratum in

  • Am J Hypertens. 2011 Feb;24(2):248. Nemwan, Anne B [corrected to Newman, Anne B]

Abstract

Background: Central arterial stiffness is increasingly recognized as an important predictor of cardiovascular events and mortality in older adults; however, few studies have evaluated the association of arterial stiffness with mobility decline, a common consequence of vascular disease.

Methods: We analyzed the association of pulse wave velocity (PWV), a measure of aortic stiffness, with longitudinal gait speed over 7 years in 2,172 participants in the Health, Aging and Body Composition (ABC) Study (mean age ± s.d. 73.6 ± 2.9 years, 48% men, 39% black).

Results: In mixed-effects models adjusted for demographics, each s.d. (396 cm/s) higher PWV was associated with 0.015 (s.e. 0.004) m/s slower gait at baseline and throughout the study period in the full cohort (P < 0.001); this relationship was largely explained by hypertension and other vascular risk factors. Among participants with peripheral arterial disease (PAD) (n = 261; 12.7%), each s.d. higher PWV was independently associated with 0.028 (s.e. 0.010) m/s slower gait speed at baseline and throughout the study period (P < 0.01).

Conclusions: These findings suggest that aortic stiffness may be especially detrimental to mobility in older adults with already compromised arterial function.

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Conflict of interest statement

Disclosure

The authors declared no conflict of interest.

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