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. 2010 Jul-Sep;15(3):462-9.

Gemcitabine plus infusional 5-fluorouracil and high dose leucovorin in advanced stage pancreatic cancer

I Oztop  1 , A Alacacioglu, I T Unek, O Tarhan, I Somali, S Cokmert, T Yavuzsen, U Yilmaz
Affiliations
  • PMID: 20941811

Gemcitabine plus infusional 5-fluorouracil and high dose leucovorin in advanced stage pancreatic cancer

I Oztop et al. J BUON. 2010 Jul-Sep.

Abstract

Purpose: Advanced pancreatic cancer (APC) has a poor prognosis and chemotherapy remains the primary treatment modality. Gemcitabine (GEM) and 5-fluorouracil (5-FU) are the most active drugs in the treatment of pancreatic cancer. This study evaluated the efficacy and tolerability of the combination of these agents in APC.

Methods: Forty-four patients with APC were treated with GEM and infusional 5-FU with high dose leucovorin (LV5FU2) (GEMFUFOL regimen).

Results: A total of 240 chemotherapy cycles were administered. The overall response rate was 27.2%, and all responses were partial. Furthermore, disease stabilization was observed in 12 patients (27.2%). Median survival time and one-year survival rate were 9 months and 36.4%, respectively. The overall grade 3 or 4 adverse events were very low and mostly hematological.

Conclusion: GEMFUFOL is still an active regimen for the treatment of APC and has an acceptable toxicity.

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