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Editorial
. 2010 Jul-Sep;23(3):709-13.
doi: 10.1177/039463201002300304.

IL-31 a Th2 cytokine involved in immunity and inflammation

M L Castellani, P Felaco, R J Galzio, D Tripodi, E Toniato, M A De Lutiis, M Fulcheri, A Caraffa, P Antinolfi, S Tetè, M Felaco, F Conti, F Pandolfi, T C Theoharides, Y B Shaik-Dasthagirisaheb
Free article
Editorial

IL-31 a Th2 cytokine involved in immunity and inflammation

M L Castellani et al. Int J Immunopathol Pharmacol. 2010 Jul-Sep.
Free article

Abstract

Cytokines are immunal regulatory proteins, however they also play a relevant role in inflammatory diseases. IL-31 is a newly discovered cytokine expressed primarily in TH2 cells, introduced by activated CD4+ T cells. IL-31 is capable of inducing chemokines and other cytokines in several inflammatory diseases via its surface receptor. This cytokine is also produced by mast cells and mast cell line, suggesting a role in allergic diseases. In this editorial we revisit the biological role of IL-31 in immunity and inflammation.

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