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. 2011 Nov;5(5):415-21.
doi: 10.1016/j.fsigen.2010.08.019. Epub 2010 Oct 13.

Development and characterization of two mini-X chromosomal short tandem repeat multiplexes

Toni M Diegoli  1 , Michael D Coble
Affiliations

Development and characterization of two mini-X chromosomal short tandem repeat multiplexes

Toni M Diegoli et al. Forensic Sci Int Genet. 2011 Nov.

Abstract

This study presents the development and characterization of two X chromosomal short tandem repeat (STR) multiplexes utilizing reduced-size amplicons (less than 200 base pairs) for identity and kinship testing with degraded DNA. Approximately 1360 samples across 4 U.S. population groups were typed for 15 X chromosomal STR markers: DXS6789, DXS7130, DXS9902, GATA31E08, DXS7424, GATA165B12, DXS101, DXS6795, GATA172D05, DXS10147, DXS8378, DXS7132, DXS6803, HPRTB, and DXS7423. A high degree of polymorphism was observed for each marker and both multiplexes were sensitive down to 200pg of pristine DNA. The two proposed multiplexes are suitable for forensic use, and show potential for improved analysis of compromised bone samples.

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