Review
doi: 10.3724/sp.j.1005.2010.01003.
[Mechanism of regulating deacetylase SIRT1 expression and activity]
[Article in
Chinese]
Affiliations
- PMID: 20943487
- DOI: 10.3724/sp.j.1005.2010.01003
Item in Clipboard
Review
[Mechanism of regulating deacetylase SIRT1 expression and activity]
[Article in
Chinese]
Yi Chuan.
2010 Oct.
Abstract
SIRT1 is an NAD+-dependent deacetylase in mammalian cells and plays important roles in senescence, cell death and tumorigenesis. To clarify the regulation of SIRT1 expression and activity is crucial for scientists to understand the biological function of SIRT1. This review mainly focuses on the mechanisms by which SIRT1 expression and activity are regulated.
Similar articles
-
Molecular Insights into SIRT1 Protection Against UVB-Induced Skin Fibroblast Senescence by Suppression of Oxidative Stress and p53 Acetylation.J Gerontol A Biol Sci Med Sci. 2015 Aug;70(8):959-68. doi: 10.1093/gerona/glu137. Epub 2014 Aug 27. J Gerontol A Biol Sci Med Sci. 2015. PMID: 25165029
-
Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming.Ageing Res Rev. 2018 May;43:64-80. doi: 10.1016/j.arr.2018.02.004. Epub 2018 Feb 21. Ageing Res Rev. 2018. PMID: 29476819 Review.
-
SIRT1 and p53, effect on cancer, senescence and beyond.Biochim Biophys Acta. 2010 Aug;1804(8):1684-9. doi: 10.1016/j.bbapap.2010.05.002. Epub 2010 May 13. Biochim Biophys Acta. 2010. PMID: 20471503 Free PMC article. Review.
-
Potential neuroprotective effects of SIRT1 induced by glucose deprivation in PC12 cells.Neurosci Lett. 2013 Dec 17;557 Pt B:148-53. doi: 10.1016/j.neulet.2013.10.050. Epub 2013 Oct 29. Neurosci Lett. 2013. PMID: 24183892
-
SIRT1 knockdown up-regulates p53 and p21/Cip1 expression in renal adenocarcinoma cells but not in normal renal-derived cells in a deacetylase-independent manner.J Toxicol Sci. 2018;43(12):711-715. doi: 10.2131/jts.43.711. J Toxicol Sci. 2018. PMID: 30518708
Cited by
-
Mechanism study on the regulation of autophagy and oxidative stress through SIRT1/PI3K/AKT pathway by Liuwei Dihuang pill to improve ovarian function.J Ovarian Res. 2025 Jun 2;18(1):118. doi: 10.1186/s13048-025-01689-0. J Ovarian Res. 2025. PMID: 40457356 Free PMC article.