Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Oct;28(10):1045-8.
doi: 10.1038/nbt1010-1045.

The NIH Roadmap Epigenomics Mapping Consortium

Bradley E Bernstein  1 , John A Stamatoyannopoulos, Joseph F Costello, Bing Ren, Aleksandar Milosavljevic, Alexander Meissner, Manolis Kellis, Marco A Marra, Arthur L Beaudet, Joseph R Ecker, Peggy J Farnham, Martin Hirst, Eric S Lander, Tarjei S Mikkelsen, James A Thomson
Affiliations

The NIH Roadmap Epigenomics Mapping Consortium

Bradley E Bernstein et al. Nat Biotechnol. 2010 Oct.

Abstract

The NIH Roadmap Epigenomics Mapping Consortium aims to produce a public resource of epigenomic maps for stem cells and primary ex vivo tissues selected to represent the normal counterparts of tissues and organ systems frequently involved in human disease.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Layers of genome organization. Genome function and cellular phenotypes are influenced by DNA methylation and the protein-DNA complex known as chromatin. In mammals, DNA methylation occurs on cytosine bases, primarily in the context of CpG dinucleotides. Accessible chromatin that is hypersensitive to DNase I digestion marks promoters and functional elements bound by transcription factors or other regulatory proteins. Histone modifications, associated proteins such as Polycomb repressors and noncoding RNAs constitute an additional layer of chromatin structure that affects genome function in a context-dependent manner.
Figure 2
Figure 2
Portal for the NIH Roadmap Epigenomics Mapping Consortium. A public portal (http://www.roadmapepigenomics.org/) provides general information about the consortium and its participants, along with links to experimental protocols, consortium data and interfaces for visualizing epigenomic maps.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Altshuler D, Daly MJ, Lander ES. Science. 2008;322:881–888. - PMC - PubMed
    1. Bird A. Nature. 2007;447:396–398. - PubMed
    1. Feinberg AP. Nature. 2007;447:433–440. - PubMed
    1. Jaenisch R, Bird A. Nat. Genet. 2003;33(Suppl):245–254. - PubMed
    1. Jones PA, Baylin SB. Cell. 2007;128:683–692. - PMC - PubMed