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Clinical Trial
. 2010 Jul-Sep;3(3):314-9.

Locally aggressive colonic and rectal cancer--clinical trial

Victor Radu  1 , Daniel Ion, Mihai Bogdan Serban, Mircea Ciurea
Affiliations
Clinical Trial

Locally aggressive colonic and rectal cancer--clinical trial

Victor Radu et al. J Med Life. 2010 Jul-Sep.

Abstract

This clinical trial studies local invasions from primary colonic and rectal cancers (urinary bladder, abdominal wall, small bowls, uterus, vagina, stomach, bile tract, spleen, duodenum, pancreas, ureters, kidneys), with or without undiscovered metastasis. Primary locally aggressive colonic and rectal cancers include tumors that are staged T4N1-2Mx on diagnosis, and are often associated with a lower prognosis than earlier cancers. Diagnosis is based on thorough clinical evaluation, imagistic support: abdominal XR with contrast (barium enema), colonoscopy, abdominal and pelvic ultrasound exam, endoscopic endolumenal ultrasound exam, abdominal and pelvic CT/IRM with contrast (administrated both orally and intravenously), PET Scan, and intra-operatory confirmation. The primary symptom was pain. Locally aggressive colonic and rectal cancers, primary or secondary, can extend to any visceral or parietal structure. The ability to perform a total resection is based upon anatomical localization and on the fixation of other organs to the lesion. Identifying the anatomical extension provides a better appreciation of the purpose of the tumoral resection. Radical nuanced surgery is the base of treatment of the locally aggressive colon-rectal cancer. The studies have shown that in certain localizations of the colon-rectal cancer, the locally aggressive forms can be better controlled by using multimodal therapy, including radiotherapy, either external or guided intraoperatory radiotherapy and chemotherapy with much better results.

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Figures

Figure 1
Figure 1
Percentage of the locally aggressive colonic–rectal cancer from all the colonic and rectal cancer studied.
Figure 2
Figure 2
Symptoms met in locally aggressive forms of the colon–rectal cancer
Figure 3
Figure 3
Colonoscopy aspects of complicated colonic–rectal cancer depending on the localization
Figure 4
Figure 4
Intra–operatory aspects
Figure 5
Figure 5
Inter–visceral or visceral–parietal fistulas
Figure 6
Figure 6
Surgical treatment of the locally aggressive colonic–rectal cancers
See this image and copyright information in PMC

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