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Review
. 2010;10(3):165-78.
doi: 10.2165/11586010-000000000-00000.

Ridaforolimus

No authors listed
Review

Ridaforolimus

No authors listed. Drugs R D. 2010.

Abstract

Ridaforolimus (AP23573; MK 8669) is an analog of sirolimus and a small molecule inhibitor of the mammalian target of rapamycin for the treatment of cancer. Both intravenous and oral formulations of the compound are being tested in clinical trials for the treatment of soft-tissue and bone sarcomas. It is in phase III development for sarcoma in the EU and US, and phase II for breast cancer, endometrial cancer, non-small cell lung cancer, and prostate cancer in the US and other markets in the world. This review discusses the key development milestones and therapeutic trials of this drug.

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Figures

Table I
Table I
Features and properties
Table II
Table II
History
Table III
Table III
Forecasts
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References

    1. ARIAD Announces Restructuring of Its Ridaforolimus Collaboration with Merck. 2010.
    1. Merck Acquires Development and Commercialization Rights to Investigational mTOR Inhibitor Ridaforolimus from ARIAD Pharmaceuticals, Inc. 2010.
    1. ARIAD and Merck & Co., Inc. Announce Global Collaboration to Jointly Develop and Commercialize AP23573 — ARIAD’s Novel mTOR Inhibitor — for Cancer. 2007.
    1. ARIAD Announces Updated Data from Clinical Trial of Its Investigational mTOR Inhibitor, Ridaforolimus, In Combination with Trastuzumab. 2009.
    1. ARIAD Announces Preliminary Data from Two Ongoing Clinical Trials of Its Investigational mTOR Inhibitor, Ridaforolimus, in Combination with Targeted Drugs. 2009.

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