Review
doi: 10.1016/j.neubiorev.2010.10.002.
Epub 2010 Oct 12.
Evidence for GABAergic inhibitory deficits in major depressive disorder
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- PMID: 20946914
- DOI: 10.1016/j.neubiorev.2010.10.002
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Review
Evidence for GABAergic inhibitory deficits in major depressive disorder
Neurosci Biobehav Rev.
2011 Jan.
Abstract
Converging evidence suggests that deficits in gamma-aminobutyric acid (GABA) functioning are implicated in the pathophysiology of major depressive disorder (MDD). This is highlighted by research investigating cortical inhibition (CI), a process whereby GABAergic interneurons selectively attenuate pyramidal neurons. Transcranial magnetic stimulation (TMS) paradigms evaluate this marker of neuronal inhibitory activity in the cortex. This review will examine the neuroanatomic and neurophysiological evidence from neuroimaging, molecular, treatment, and TMS studies linking dysfunctional GABAergic neurotransmission to MDD.
Copyright © 2010 Elsevier Ltd. All rights reserved.
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