Finding a diamond in the (mouse is) rough
- PMID: 20947688
- DOI: 10.1182/blood-2010-07-296780
Finding a diamond in the (mouse is) rough
Abstract
In this issue of Blood, Devlin and colleagues use a new strategy to create a mouse model for the inherited bone marrow failure syndrome, DBA.The result, while recapitulating certain aspects of the disease and representing a positive step forward, also demonstrates that significant hurdles remain in faithfully creating a mammalian model for DBA.
Comment on
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A transgenic mouse model demonstrates a dominant negative effect of a point mutation in the RPS19 gene associated with Diamond-Blackfan anemia.Blood. 2010 Oct 14;116(15):2826-35. doi: 10.1182/blood-2010-03-275776. Epub 2010 Jul 6. Blood. 2010. PMID: 20606162 Free PMC article.
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