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Comment
. 2010 Oct 14;116(15):2858-9.
doi: 10.1182/blood-2010-06-291104.

Toxic effects of sorafenib when given early after allogeneic hematopoietic stem cell transplantation

Hisayuki Yokoyama, Andreas Lundqvist, Su Su, Richard Childs
Comment

Toxic effects of sorafenib when given early after allogeneic hematopoietic stem cell transplantation

Hisayuki Yokoyama et al. Blood. .
No abstract available

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Figures

Figure 1
Figure 1
Sorafenib worsens GVHD and shortens survival when given after a T cell–replete allogeneic SCT in mice with RENCA tumors. GVHD score and survival in tumor bearing mice undergoing allogeneic SCT using BM + splenocytes with or with sorafenib given by oral gavage after transplantation. GVHD score was assessed by the following symptoms: alopecia (0-4 points), hunched posture (0-2 points), ear or eye irritation (0-1 points). Error bars (left panel) show standard error of the mean.
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Comment on

References

    1. Metzelder S, Wang Y, Wollmer E, et al. Compassionate use of sorafenib in FLT3-ITD–positive acute myeloid leukemia: sustained regression before and after allogeneic stem cell transplantation. Blood. 2009;113(26):6567–6571. - PubMed