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. 2010 Nov;16(11):1241-7.
doi: 10.1038/nm.2230. Epub 2010 Oct 14.

Overcoming obstacles to developing new analgesics

Clifford J Woolf  1
Affiliations

Overcoming obstacles to developing new analgesics

Clifford J Woolf. Nat Med. 2010 Nov.

Abstract

Despite substantial investment by the pharmaceutical industry over several decades, there has been little progress in developing new, efficacious and safe analgesics. As a result, many large pharmaceutical companies are leaving the area of pain medication. Nevertheless, the chances of success could increase if analgesic drug development strategy changed. To achieve such a paradigm shift we must understand why development of drugs for pain relief is so challenging.

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