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. 2009 Sep 28:1:71.
doi: 10.3410/B1-71.

HIV-1 host interactions: integration of large-scale datasets

Amalio Telenti  1
Affiliations

HIV-1 host interactions: integration of large-scale datasets

Amalio Telenti. F1000 Biol Rep. .

Abstract

HIV-1 replication and viral pathogenesis are dependent on numerous host factors. A series of recent papers apply genome-wide and large-scale approaches to map host-virus interactions and to identify host proteins capable of restricting (that is, controlling) the virus. Strategies include genome-wide association studies, small interfering RNA screens, genome-wide transcriptome profiling, proteome studies, and the assessment of the role of host-encoded microRNAs in infection. The various layers of large-scale data are brought together through meta-analytical procedures.

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Figures

Figure 1.
Figure 1.. Genome-wide and large-scale cellular studies published since 2007 in the field of HIV
The number of studies is in parenthesis. Diverse sets of results and data are compiled in an encyclopedia of overlaps between studies [32]. This approach serves to identify networks used by HIV-1 to support its replication. miRNA, microRNA; siRNA, short interfering RNA.
See this image and copyright information in PMC

References

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    2. F1000 Factor 6.0 Must Read

      Evaluated by Amalio Telenti 08 Jun 2009

    1. Telenti A. Evaluation of: Bushman FD, Malani N, Fernandes J, D’Orso I, Cagney G, Diamond TL, Zhou H, Hazuda DJ, Espeseth AS, Konig R, Bandyopadhyay S, Ideker T, Goff SP, Krogan NJ, Frankel AD, Young JA, Chanda SK: Host cell factors in HIV replication: meta-analysis of genome-wide studies. PLoS Pathog. 2009, 5:e1000437. - PMC - PubMed

    2. Faculty of 1000 Medicine, 8 Jun 2009

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