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. 2009 Jul 8:1:54.
doi: 10.3410/B1-54.

A current view of Alzheimer's disease

Basavaraj V Hooli  1 , Rudolph E Tanzi
Affiliations

A current view of Alzheimer's disease

Basavaraj V Hooli et al. F1000 Biol Rep. .

Abstract

Several genes that influence susceptibility to Alzheimer's disease (AD) have been known for over two decades. Recent advances have elucidated novel candidate genes and the pathogenetic mechanisms underlying neurodegeneration in AD. Here, we summarize what we have learned from studies of the known AD genes with regard to the causes of AD and emerging therapies. We also review key recent discoveries that have enhanced our understanding of the etiology and pathogenesis of this devastating disease, based on new investigations into the genes and molecular mechanisms underlying AD.

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Figures

Figure 1a.
Figure 1a.. Aβ-induced internalization of synaptic NMDA and AMPA receptors
Figure 1b.
Figure 1b.. Synaptic Aβ hypothesis
See this image and copyright information in PMC

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