Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Jan 18:2:3.
doi: 10.3410/B2-3.

Ocular immune privilege

Ru Zhou  1 , Rachel R Caspi
Affiliations

Ocular immune privilege

Ru Zhou et al. F1000 Biol Rep. .

Abstract

The eye attempts to limit local immune and inflammatory responses to preserve vision. This phenomenon, known as ocular immune privilege, is mediated by a combination of local and systemic mechanisms. While immune privilege is believed to protect the eye from day-to-day inflammatory insults, it is not absolute and its mechanisms are still incompletely understood.

PubMed Disclaimer

References

    1. Medawar PB. Immunity to homologous grafted skin; the fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye. Br J Exp Pathol. 1948;29:58–69. - PMC - PubMed
    1. Streilein JW. Ocular immune privilege: the eye takes a dim but practical view of immunity and inflammation. J Leukoc Biol. 2003;74:179–85. doi: 10.1189/jlb.1102574. - DOI - PubMed
    1. Caspi RR, Roberge FG, Nussenblatt RB. Organ-resident, nonlymphoid cells suppress proliferation of autoimmune T-helper lymphocytes. Science. 1987;237:1029–32. doi: 10.1126/science.2956685. - DOI - PubMed
    1. Stein-Streilein J. Immune regulation and the eye. Trends Immunol. 2008;29:548–54. doi: 10.1016/j.it.2008.08.002. - DOI - PubMed
    1. Taylor AW. Ocular immunosuppressive microenvironment. Chem Immunol Allergy. 2007;92:71–85. doi: 10.1159/000099255. - DOI - PubMed