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. 2010 Mar 15:2:19.
doi: 10.3410/B2-19.

Control of Schwann cell myelination

Kristján R Jessen  1 , Rhona Mirsky
Affiliations

Control of Schwann cell myelination

Kristján R Jessen et al. F1000 Biol Rep. .

Abstract

Schwann cells ensheath all axons of peripheral nerves. Only around large-diameter axons do they elaborate myelin, forming insulating sheaths that are vital for fast conduction of axon potentials. A series of recent papers has illuminated some of the ways in which the process of myelination is controlled, both by signals from axons and by positive and negative transcriptional mechanisms within the Schwann cells themselves.

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References

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    2. <ext-link ext-link-type="uri" xlink:href="http://www.f1000biology.com/article/id/1014719">f1000 Factor 3.2 Recommended</ext-link>

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    1. Taveggia C, Zanazzi G, Petrylak A, Yano H, Rosenbluth J, Einheber S, Xu X, Esper RM, Loeb JA, Shrager P, Chao MV, Falls DL, Role L, Salzer JL. Neuregulin-1 type III determines the ensheathment fate of axons. Neuron. 2005;47:681–94. doi: 10.1016/j.neuron.2005.08.017. - DOI - PMC - PubMed

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