Past and current tendency for facial flushing after a small dose of alcohol is a marker for increased risk of upper aerodigestive tract cancer in Japanese drinkers

Comment

Akira Yokoyama et al. Cancer Sci. 2010 Nov.

. 2010 Nov;101(11):2497-8; author reply 2499-500.

doi: 10.1111/j.1349-7006.2010.01709.x.

Abstract

(Cancer Sci 2010; 101: 2497–2498)

Comparison between self-reported facial flushing after alcohol consumption and ALDH2 Glu504Lys polymorphism for risk of upper aerodigestive tract cancer in a Japanese population.
Oze I, Matsuo K, Hosono S, Ito H, Kawase T, Watanabe M, Suzuki T, Hatooka S, Yatabe Y, Hasegawa Y, Shinoda M, Tajima K, Tanaka H. Oze I, et al. Cancer Sci. 2010 Aug;101(8):1875-80. doi: 10.1111/j.1349-7006.2010.01599.x. Epub 2010 Apr 23. Cancer Sci. 2010. PMID: 20518787 Free PMC article.

1. Oze I, Matsuo K, Hosono S et al. Comparison between self‐reported facial flushing after alcohol consumption and ALDH2 Glu504Lys polymorphisms for risk of upper aerodigestive tract cancer in a Japanese population. Cancer Sci 2010; 101: 1875–80. - PMC - PubMed
1. Secretan B, Straif K, Baan R et al. A review of human carcinogens‐Part E: tobacco, areca nut, alcohol, coal smoke, and salted fish. Lancet Oncol 2009; 10: 1033–4. - PubMed
1. Brooks PJ, Enoch MA, Doldman D, Li TK, Yokoyama A. The alcohol flushing response: an unrecognized risk factor of esophageal cancer from alcohol consumption. PLoS Med 2009; 6: e50. - PMC - PubMed
1. Higuchi S, Muramatsu T, Shigemori K et al. The relationship between low Km aldehyde dehydrogenase phenotype and drinking behavior in Japanese. J Stud Alcohol 1992; 53: 170–5. - PubMed
1. Ishiguro S, Sasazuki S, Inoue M et al. Effect of alcohol consumption, cigarette smoking and flushing response on esophageal cancer risk: a population‐based cohort study (JPHC study). Cancer Lett 2009; 275: 240–6. - PubMed