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Comment
. 2010 Oct 30;376(9751):1441-2.
doi: 10.1016/S0140-6736(10)61497-3. Epub 2010 Oct 14.

Curing hepatitis C with pills: a step toward global control

David L Thomas  1
Affiliations
Comment

Curing hepatitis C with pills: a step toward global control

David L Thomas. Lancet. .
No abstract available

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Figures

Figure 1
Figure 1
Schematic representation of low global impact of improving HCV treatment efficacy without expanding HCV testing and treatment initiation. A=overall sustained virological response rates (SVR) possible with major developments in HCV treatment and projections of 90% SVR with new drugs. B=population impact calculated by multiplying efficacy figures from A by estimate of percent of individuals worldwide who have started HCV treatment. 2001 shown because pegylated interferon alfa and ribavirin were first approved then (peginterferon alfa 2a approved in 2002), the latest upgrade in HCV treatment
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References

    1. McHutchison JG, Everson GT, Gordon SC, et al. Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection. N Engl J Med. 2009;360:1827–1838. - PubMed
    1. Kwo PY, Lawitz EJ, McCone J, et al. Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial. Lancet. 2010;376:705–716. - PubMed
    1. Gane, et al. Lancet
    1. Fried MW, Shiffman ML, Reddy KR, et al. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med. 2002;347:975–982. - PubMed
    1. McHutchison JG, Lawitz EJ, Shiffman ML, et al. Peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis C infection. N Engl J Med. 2009;361:580–593. - PubMed

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