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. 2010 Nov 12;402(2):324-8.
doi: 10.1016/j.bbrc.2010.10.025. Epub 2010 Oct 15.

Cell-specific regulation of Fas exon 6 splicing mediated by Hu antigen R

José M Izquierdo  1
Affiliations

Cell-specific regulation of Fas exon 6 splicing mediated by Hu antigen R

José M Izquierdo. Biochem Biophys Res Commun. .

Abstract

The differential expression levels of T-cell intracellular antigens (TIA) and Hu antigen R (HuR) are concomitant with a splicing switch in apoptosis receptor Fas in HCT-116 cells. Thus, overexpression and knockdown of HuR led to Fas exon 6 skipping and inclusion, respectively. These results suggest that the TIA and HuR cellular ratio influences cell-type specific Fas exon 6 splicing pattern.

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