Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011 Feb;9(2):181-3.
doi: 10.1016/j.cgh.2010.10.002. Epub 2010 Oct 15.

Evidence of persistent cognitive impairment after resolution of overt hepatic encephalopathy

Oliviero Riggio  1 , Lorenzo Ridola, Chiara Pasquale, Silvia Nardelli, Ilaria Pentassuglio, Federica Moscucci, Manuela Merli
Affiliations

Evidence of persistent cognitive impairment after resolution of overt hepatic encephalopathy

Oliviero Riggio et al. Clin Gastroenterol Hepatol. 2011 Feb.

Abstract

Background & aims: The Inhibitory Control Test has been proposed as a tool to detect the persistence of cognitive defects after the resolution of overt hepatic encephalopathy (OHE). We tested learning abilities of cirrhotic patients using the Psychometric Hepatic Encephalopathy Score (PHES).

Methods: One hundred six cirrhotic patients who agreed to be examined twice within 3 days were studied using the PHES. Twenty-seven patients had previous OHE; of the remaining 79 patients, 34 were affected by minimal HE and 45 were normal.

Results: Among patients without previous OHE, PHESs significantly improved at the second examination; this learning effect was present in the patients with or without minimal HE. To the contrary, learning ability was lost in patients with previous OHE. Even among the 8 patients with history of HE and normal PHESs in the first examination, repeated testing showed a lack of learning capacity.

Conclusions: HE is not a fully reversible condition. Residual cognitive impairments should be evaluated by specific tests, based on patients' learning capacities.

PubMed Disclaimer

Comment in

Publication types