Comment
doi: 10.1016/j.ccr.2010.10.005.
MicroRNA biogenesis takes another single hit from microsatellite instability
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- PMID: 20951937
- DOI: 10.1016/j.ccr.2010.10.005
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Comment
MicroRNA biogenesis takes another single hit from microsatellite instability
Cancer Cell.
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Free article
Abstract
In this issue of Cancer Cell, Melo et al. show that mutation of a single allele of the Exportin-5 gene (XPO5) suffices to depress microRNA (miRNA) levels and promote tumorigenesis. Thus, XPO5 joins the ranks of DICER and TRBP as a haploinsufficient tumor suppressor in the miRNA biogenesis pathway.
Copyright © 2010 Elsevier Inc. All rights reserved.
Comment on
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A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells.Cancer Cell. 2010 Oct 19;18(4):303-15. doi: 10.1016/j.ccr.2010.09.007. Cancer Cell. 2010. PMID: 20951941
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