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Comment
. 2010 Oct 19;18(4):295-7.
doi: 10.1016/j.ccr.2010.10.005.

MicroRNA biogenesis takes another single hit from microsatellite instability

Helge Grosshans  1 , Ingo Büssing
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MicroRNA biogenesis takes another single hit from microsatellite instability

Helge Grosshans et al. Cancer Cell. .
Free article

Abstract

In this issue of Cancer Cell, Melo et al. show that mutation of a single allele of the Exportin-5 gene (XPO5) suffices to depress microRNA (miRNA) levels and promote tumorigenesis. Thus, XPO5 joins the ranks of DICER and TRBP as a haploinsufficient tumor suppressor in the miRNA biogenesis pathway.

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